rs2740574

What is the rs2740574 variant?

rs2740574 is a SNP (single nucleotide polymorphism) in the CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) gene. It belongs to the Drug Metabolism category and is part of the Detox & Medication Sensitivity biological cluster. CYP3A4 is the most abundantly expressed hepatic CYP enzyme, metabolizing over 50% of clinically used drugs.

Biological role and pathway

This variant sits within the CYP3A4 gene, which is involved in the Phase I xenobiotic metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: CYP3A4

rs2740574 is one of 1 known variant in the CYP3A4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2740574

Research into CYP3A4 variants including rs2740574 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYP3A4 and the rs2740574 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions