rs321029
Variant in the CYSLTR1 gene (Cysteinyl Leukotriene Receptor 1)
rs321029 is a single nucleotide polymorphism (SNP) in the CYSLTR1 gene, involved in leukotriene signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs321029 variant?
rs321029 is a SNP (single nucleotide polymorphism) in the CYSLTR1 (Cysteinyl Leukotriene Receptor 1) gene. It belongs to the Inflammation category and is part of the Immune System & Inflammation biological cluster. CysLT1R mediates bronchoconstriction, mucus secretion, and eosinophil recruitment in response to LTC4, LTD4, and LTE4. It is the target of montelukast and other leukotriene receptor antagonists used for asthma.
Biological role and pathway
This variant sits within the CYSLTR1 gene, which is involved in the leukotriene signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs321029 and Long COVID / ME-CFS research
Cysteinyl leukotriene signaling is implicated in COVID-19 respiratory pathology. Montelukast (CysLT1R antagonist) has shown benefit in some Long COVID trials. CYSLTR1 variants affecting receptor expression or signaling may influence respiratory symptom severity in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CYSLTR1
rs321029 is one of 2 known variants in the CYSLTR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CYSLTR1 gene page →Conditions studied in relation to rs321029
Research into CYSLTR1 variants including rs321029 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CYSLTR1 and the rs321029 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CYSLTR1 gene
The following variants in CYSLTR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs321029 variant in the CYSLTR1 gene?
rs321029 is a single nucleotide polymorphism (SNP) located in the CYSLTR1 (Cysteinyl Leukotriene Receptor 1) gene, which is involved in leukotriene signaling. CysLT1R mediates bronchoconstriction, mucus secretion, and eosinophil recruitment in response to LTC4, LTD4, and LTE4. It is the target of montelukast and other leukotriene receptor antagonists used for asthma.
How may the rs321029 variant relate to Long COVID or ME/CFS?
Cysteinyl leukotriene signaling is implicated in COVID-19 respiratory pathology. Montelukast (CysLT1R antagonist) has shown benefit in some Long COVID trials. CYSLTR1 variants affecting receptor expression or signaling may influence respiratory symptom severity in Long COVID.
Can a consumer DNA test detect the rs321029 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs321029 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CYSLTR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 35190839
- [2]Lancet
- [3]Journal of Allergy and Clinical Immunology