rs77905

What is the rs77905 variant?

rs77905 is a SNP (single nucleotide polymorphism) in the DBH (Dopamine Beta-Hydroxylase) gene. It belongs to the Neurotransmitter category and is part of the Autonomic Nervous System biological cluster. DBH encodes dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine in sympathetic neurons and the adrenal medulla.

Biological role and pathway

This variant sits within the DBH gene, which is involved in the norepinephrine biosynthesis pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: DBH

rs77905 is one of 2 known variants in the DBH gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs77905

Research into DBH variants including rs77905 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DBH and the rs77905 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the DBH gene

The following variants in DBH are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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