rs3010326
Variant in the DDC gene (Dopa Decarboxylase)
rs3010326 is a single nucleotide polymorphism (SNP) in the DDC gene, involved in monoamine synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3010326 variant?
rs3010326 is a SNP (single nucleotide polymorphism) in the DDC (Dopa Decarboxylase) gene. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. DDC encodes aromatic amino acid decarboxylase, which converts L-DOPA to dopamine and 5-HTP to serotonin.
Biological role and pathway
This variant sits within the DDC gene, which is involved in the monoamine synthesis pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3010326 and Long COVID / ME-CFS research
DDC function bridges the biosynthesis of both dopaminergic and serotonergic systems, both relevant to mood and cognitive symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DDC
rs3010326 is one of 1 known variant in the DDC gene. To understand the full biological context of this variant, explore the parent gene page.
View DDC gene page →Conditions studied in relation to rs3010326
Research into DDC variants including rs3010326 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DDC and the rs3010326 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs3010326 variant in the DDC gene?
rs3010326 is a single nucleotide polymorphism (SNP) located in the DDC (Dopa Decarboxylase) gene, which is involved in monoamine synthesis. DDC encodes aromatic amino acid decarboxylase, which converts L-DOPA to dopamine and 5-HTP to serotonin.
How may the rs3010326 variant relate to Long COVID or ME/CFS?
DDC function bridges the biosynthesis of both dopaminergic and serotonergic systems, both relevant to mood and cognitive symptoms in Long COVID.
Can a consumer DNA test detect the rs3010326 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3010326 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DDC and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Clinical Investigation