rs3205166
Variant in the DDX58 gene (DExD/H-Box Helicase 58)
rs3205166 is a single nucleotide polymorphism (SNP) in the DDX58 gene, involved in RLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3205166 variant?
rs3205166 is a SNP (single nucleotide polymorphism) in the DDX58 (DExD/H-Box Helicase 58) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. DDX58 (RIG-I) is a cytoplasmic RNA helicase that senses short double-stranded and 5'-triphosphate single-stranded RNA as an early pattern recognition receptor for RNA viruses, signaling through MAVS to activate interferon production.
Biological role and pathway
This variant sits within the DDX58 gene, which is involved in the RLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3205166 and Long COVID / ME-CFS research
RIG-I is among the first sensors of SARS-CoV-2 RNA. DDX58 polymorphisms may affect the speed and magnitude of initial innate immune responses to SARS-CoV-2, influencing both acute COVID-19 severity and Long COVID predisposition.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DDX58
rs3205166 is one of 3 known variants in the DDX58 gene. To understand the full biological context of this variant, explore the parent gene page.
View DDX58 gene page →Conditions studied in relation to rs3205166
Research into DDX58 variants including rs3205166 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DDX58 and the rs3205166 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DDX58 gene
The following variants in DDX58 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3205166 variant in the DDX58 gene?
rs3205166 is a single nucleotide polymorphism (SNP) located in the DDX58 (DExD/H-Box Helicase 58) gene, which is involved in RLR signaling. DDX58 (RIG-I) is a cytoplasmic RNA helicase that senses short double-stranded and 5'-triphosphate single-stranded RNA as an early pattern recognition receptor for RNA viruses, signaling through MAVS to activate interferon production.
How may the rs3205166 variant relate to Long COVID or ME/CFS?
RIG-I is among the first sensors of SARS-CoV-2 RNA. DDX58 polymorphisms may affect the speed and magnitude of initial innate immune responses to SARS-CoV-2, influencing both acute COVID-19 severity and Long COVID predisposition.
Can a consumer DNA test detect the rs3205166 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3205166 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DDX58 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33794154
- [2]Nature Immunology
- [3]Cell