rs6047772
Variant in the DDX60 gene (DExD/H-Box Helicase 60)
rs6047772 is a single nucleotide polymorphism (SNP) in the DDX60 gene, involved in antiviral response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6047772 variant?
rs6047772 is a SNP (single nucleotide polymorphism) in the DDX60 (DExD/H-Box Helicase 60) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. DDX60 is an ISG and RNA helicase that facilitates RIG-I and MDA5 antiviral signaling by binding viral RNA. It is induced by interferons and enhances innate immune detection of RNA viruses.
Biological role and pathway
This variant sits within the DDX60 gene, which is involved in the antiviral response pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6047772 and Long COVID / ME-CFS research
DDX60 is among the most highly induced genes in severe COVID-19 transcriptomes. Its amplification of RIG-I/MDA5 antiviral signaling means variants affecting DDX60 may influence the efficiency and duration of interferon responses during SARS-CoV-2 infection.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DDX60
rs6047772 is one of 2 known variants in the DDX60 gene. To understand the full biological context of this variant, explore the parent gene page.
View DDX60 gene page →Conditions studied in relation to rs6047772
Research into DDX60 variants including rs6047772 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DDX60 and the rs6047772 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DDX60 gene
The following variants in DDX60 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6047772 variant in the DDX60 gene?
rs6047772 is a single nucleotide polymorphism (SNP) located in the DDX60 (DExD/H-Box Helicase 60) gene, which is involved in antiviral response. DDX60 is an ISG and RNA helicase that facilitates RIG-I and MDA5 antiviral signaling by binding viral RNA. It is induced by interferons and enhances innate immune detection of RNA viruses.
How may the rs6047772 variant relate to Long COVID or ME/CFS?
DDX60 is among the most highly induced genes in severe COVID-19 transcriptomes. Its amplification of RIG-I/MDA5 antiviral signaling means variants affecting DDX60 may influence the efficiency and duration of interferon responses during SARS-CoV-2 infection.
Can a consumer DNA test detect the rs6047772 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6047772 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DDX60 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25415050
- [2]Immunity
- [3]Journal of Virology