rs35677470
Variant in the DNASE1L3 gene (Deoxyribonuclease 1 Like 3)
rs35677470 is a single nucleotide polymorphism (SNP) in the DNASE1L3 gene, involved in nucleic acid sensing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs35677470 variant?
rs35677470 is a SNP (single nucleotide polymorphism) in the DNASE1L3 (Deoxyribonuclease 1 Like 3) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. DNASE1L3 degrades extracellular chromatin released from dying cells, particularly neutrophil extracellular traps (NETs). Deficiency causes lupus-like disease due to accumulation of immunogenic DNA complexes.
Biological role and pathway
This variant sits within the DNASE1L3 gene, which is involved in the nucleic acid sensing pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs35677470 and Long COVID / ME-CFS research
Elevated NETs are documented in COVID-19 and Long COVID, contributing to microthrombi and inflammation. DNASE1L3 variants impairing NET clearance may worsen the NET-driven coagulopathy and vascular damage in post-COVID syndrome.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DNASE1L3
rs35677470 is one of 3 known variants in the DNASE1L3 gene. To understand the full biological context of this variant, explore the parent gene page.
View DNASE1L3 gene page →Conditions studied in relation to rs35677470
Research into DNASE1L3 variants including rs35677470 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DNASE1L3 and the rs35677470 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DNASE1L3 gene
The following variants in DNASE1L3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs35677470 variant in the DNASE1L3 gene?
rs35677470 is a single nucleotide polymorphism (SNP) located in the DNASE1L3 (Deoxyribonuclease 1 Like 3) gene, which is involved in nucleic acid sensing. DNASE1L3 degrades extracellular chromatin released from dying cells, particularly neutrophil extracellular traps (NETs). Deficiency causes lupus-like disease due to accumulation of immunogenic DNA complexes.
How may the rs35677470 variant relate to Long COVID or ME/CFS?
Elevated NETs are documented in COVID-19 and Long COVID, contributing to microthrombi and inflammation. DNASE1L3 variants impairing NET clearance may worsen the NET-driven coagulopathy and vascular damage in post-COVID syndrome.
Can a consumer DNA test detect the rs35677470 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs35677470 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DNASE1L3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30143595
- [2]Nature Genetics
- [3]Journal of Experimental Medicine