rs36012910

What is the rs36012910 variant?

rs36012910 is a SNP (single nucleotide polymorphism) in the DNMT3A (DNA Methyltransferase 3 Alpha) gene. It belongs to the Epigenetics category and is part of the Epigenetics & Gene Regulation biological cluster. DNMT3A encodes a de novo DNA methyltransferase that establishes new methylation patterns on CpG sites during development and in response to environmental signals.

Biological role and pathway

This variant sits within the DNMT3A gene, which is involved in the de novo DNA methylation pathway. Genes within the Epigenetics & Gene Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: DNMT3A

rs36012910 is one of 2 known variants in the DNMT3A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs36012910

Research into DNMT3A variants including rs36012910 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DNMT3A and the rs36012910 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the DNMT3A gene

The following variants in DNMT3A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions