rs1558957
Variant in the DPP4 gene (Dipeptidyl Peptidase 4 (CD26))
rs1558957 is a single nucleotide polymorphism (SNP) in the DPP4 gene, involved in co-receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1558957 variant?
rs1558957 is a SNP (single nucleotide polymorphism) in the DPP4 (Dipeptidyl Peptidase 4 (CD26)) gene. It belongs to the Viral Entry category and is part of the Viral Entry & Receptors biological cluster. DPP4 encodes CD26, a multifunctional protein with peptidase activity that acts as a co-receptor for MERS-CoV and affects immune cell function.
Biological role and pathway
This variant sits within the DPP4 gene, which is involved in the co-receptor signaling pathway. Genes within the Viral Entry & Receptors cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1558957 and Long COVID / ME-CFS research
DPP4 inhibitors are being studied for Long COVID metabolic and inflammatory features, with potential effects on immune cell activation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DPP4
rs1558957 is one of 2 known variants in the DPP4 gene. To understand the full biological context of this variant, explore the parent gene page.
View DPP4 gene page →Conditions studied in relation to rs1558957
Research into DPP4 variants including rs1558957 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DPP4 and the rs1558957 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DPP4 gene
The following variants in DPP4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1558957 variant in the DPP4 gene?
rs1558957 is a single nucleotide polymorphism (SNP) located in the DPP4 (Dipeptidyl Peptidase 4 (CD26)) gene, which is involved in co-receptor signaling. DPP4 encodes CD26, a multifunctional protein with peptidase activity that acts as a co-receptor for MERS-CoV and affects immune cell function.
How may the rs1558957 variant relate to Long COVID or ME/CFS?
DPP4 inhibitors are being studied for Long COVID metabolic and inflammatory features, with potential effects on immune cell activation.
Can a consumer DNA test detect the rs1558957 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1558957 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DPP4 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32142651
- [2]Nature Genetics
- [3]Journal of Clinical Investigation