rs1800955
Variant in the DRD4 gene (Dopamine Receptor D4)
rs1800955 is a single nucleotide polymorphism (SNP) in the DRD4 gene, involved in dopamine D4 receptor / prefrontal cortex. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800955 variant?
rs1800955 is a SNP (single nucleotide polymorphism) in the DRD4 (Dopamine Receptor D4) gene. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. DRD4 encodes the D4 dopamine receptor, highly expressed in the prefrontal cortex and associated with attention and novelty seeking.
Biological role and pathway
This variant sits within the DRD4 gene, which is involved in the dopamine D4 receptor / prefrontal cortex pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800955 and Long COVID / ME-CFS research
DRD4 variants (VNTR, rs1800955) affect prefrontal dopamine signaling; they may influence cognitive symptoms and executive function impairment in Long COVID brain fog.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DRD4
rs1800955 is one of 2 known variants in the DRD4 gene. To understand the full biological context of this variant, explore the parent gene page.
View DRD4 gene page →Conditions studied in relation to rs1800955
Research into DRD4 variants including rs1800955 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DRD4 and the rs1800955 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DRD4 gene
The following variants in DRD4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800955 variant in the DRD4 gene?
rs1800955 is a single nucleotide polymorphism (SNP) located in the DRD4 (Dopamine Receptor D4) gene, which is involved in dopamine D4 receptor / prefrontal cortex. DRD4 encodes the D4 dopamine receptor, highly expressed in the prefrontal cortex and associated with attention and novelty seeking.
How may the rs1800955 variant relate to Long COVID or ME/CFS?
DRD4 variants (VNTR, rs1800955) affect prefrontal dopamine signaling; they may influence cognitive symptoms and executive function impairment in Long COVID brain fog.
Can a consumer DNA test detect the rs1800955 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800955 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for DRD4 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Molecular Psychiatry