rs3816248

What is the rs3816248 variant?

rs3816248 is a SNP (single nucleotide polymorphism) in the DNM1L (Dynamin 1 Like (DRP1)) gene. It belongs to the Mitochondrial Dynamics category and is part of the Mitochondrial Energy Production & PEM biological cluster. DNM1L encodes DRP1 (dynamin-related protein 1), the primary GTPase mediating mitochondrial fission.

Biological role and pathway

This variant sits within the DNM1L gene, which is involved in the mitochondrial fission pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: DNM1L

rs3816248 is one of 1 known variant in the DNM1L gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3816248

Research into DNM1L variants including rs3816248 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DNM1L and the rs3816248 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions