rs760761
Variant in the DTNBP1 gene (Dystrobrevin Binding Protein 1 (Dysbindin))
rs760761 is a single nucleotide polymorphism (SNP) in the DTNBP1 gene, involved in dopaminergic and glutamatergic regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs760761 variant?
rs760761 is a SNP (single nucleotide polymorphism) in the DTNBP1 (Dystrobrevin Binding Protein 1 (Dysbindin)) gene. It belongs to the Neuroplasticity category and is part of the Neurological & Cognitive Function biological cluster. DTNBP1 encodes dysbindin, which regulates synaptic vesicle biology and is involved in dopaminergic and glutamatergic neurotransmission.
Biological role and pathway
This variant sits within the DTNBP1 gene, which is involved in the dopaminergic and glutamatergic regulation pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs760761 and Long COVID / ME-CFS research
DTNBP1 variants affecting synaptic function may contribute to cognitive and memory deficits associated with Long COVID brain fog.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: DTNBP1
rs760761 is one of 2 known variants in the DTNBP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View DTNBP1 gene page →Conditions studied in relation to rs760761
Research into DTNBP1 variants including rs760761 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include DTNBP1 and the rs760761 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the DTNBP1 gene
The following variants in DTNBP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs760761 variant in the DTNBP1 gene?
rs760761 is a single nucleotide polymorphism (SNP) located in the DTNBP1 (Dystrobrevin Binding Protein 1 (Dysbindin)) gene, which is involved in dopaminergic and glutamatergic regulation. DTNBP1 encodes dysbindin, which regulates synaptic vesicle biology and is involved in dopaminergic and glutamatergic neurotransmission.
How may the rs760761 variant relate to Long COVID or ME/CFS?
DTNBP1 variants affecting synaptic function may contribute to cognitive and memory deficits associated with Long COVID brain fog.
Can a consumer DNA test detect the rs760761 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs760761 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for DTNBP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Clinical Investigation