rs17337023
Variant in the EGFR gene (Epidermal Growth Factor Receptor)
rs17337023 is a single nucleotide polymorphism (SNP) in the EGFR gene, involved in EGF receptor / ERK and PI3K signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs17337023 variant?
rs17337023 is a SNP (single nucleotide polymorphism) in the EGFR (Epidermal Growth Factor Receptor) gene. It belongs to the Signaling category and is part of the Respiratory & Lung Function biological cluster. EGFR encodes the EGF receptor, a receptor tyrosine kinase that mediates epithelial cell proliferation, survival, and repair.
Biological role and pathway
This variant sits within the EGFR gene, which is involved in the EGF receptor / ERK and PI3K signaling pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs17337023 and Long COVID / ME-CFS research
EGFR drives airway epithelial repair after COVID-19 injury; SARS-CoV-2 can directly activate EGFR signaling, and variants may affect epithelial regeneration and fibrotic responses in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: EGFR
rs17337023 is one of 2 known variants in the EGFR gene. To understand the full biological context of this variant, explore the parent gene page.
View EGFR gene page →Conditions studied in relation to rs17337023
Research into EGFR variants including rs17337023 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include EGFR and the rs17337023 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the EGFR gene
The following variants in EGFR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs17337023 variant in the EGFR gene?
rs17337023 is a single nucleotide polymorphism (SNP) located in the EGFR (Epidermal Growth Factor Receptor) gene, which is involved in EGF receptor / ERK and PI3K signaling. EGFR encodes the EGF receptor, a receptor tyrosine kinase that mediates epithelial cell proliferation, survival, and repair.
How may the rs17337023 variant relate to Long COVID or ME/CFS?
EGFR drives airway epithelial repair after COVID-19 injury; SARS-CoV-2 can directly activate EGFR signaling, and variants may affect epithelial regeneration and fibrotic responses in Long COVID.
Can a consumer DNA test detect the rs17337023 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs17337023 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for EGFR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell