rs1683564
Variant in the ELANE gene (Elastase Neutrophil Expressed)
rs1683564 is a single nucleotide polymorphism (SNP) in the ELANE gene, involved in neutrophil serine protease / NET formation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1683564 variant?
rs1683564 is a SNP (single nucleotide polymorphism) in the ELANE (Elastase Neutrophil Expressed) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. ELANE encodes neutrophil elastase, a serine protease in neutrophil granules that degrades extracellular matrix components and drives NET formation.
Biological role and pathway
This variant sits within the ELANE gene, which is involved in the neutrophil serine protease / NET formation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1683564 and Long COVID / ME-CFS research
Neutrophil elastase and NETs are elevated in COVID-19 and contribute to endothelial damage and coagulopathy; ELANE variants may affect NET-mediated tissue injury in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ELANE
rs1683564 is one of 2 known variants in the ELANE gene. To understand the full biological context of this variant, explore the parent gene page.
View ELANE gene page →Conditions studied in relation to rs1683564
Research into ELANE variants including rs1683564 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ELANE and the rs1683564 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ELANE gene
The following variants in ELANE are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1683564 variant in the ELANE gene?
rs1683564 is a single nucleotide polymorphism (SNP) located in the ELANE (Elastase Neutrophil Expressed) gene, which is involved in neutrophil serine protease / NET formation. ELANE encodes neutrophil elastase, a serine protease in neutrophil granules that degrades extracellular matrix components and drives NET formation.
How may the rs1683564 variant relate to Long COVID or ME/CFS?
Neutrophil elastase and NETs are elevated in COVID-19 and contribute to endothelial damage and coagulopathy; ELANE variants may affect NET-mediated tissue injury in Long COVID.
Can a consumer DNA test detect the rs1683564 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1683564 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ELANE and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Blood