rs72935865
Variant in the EOMES gene (Eomesodermin)
rs72935865 is a single nucleotide polymorphism (SNP) in the EOMES gene, involved in T cell effector function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs72935865 variant?
rs72935865 is a SNP (single nucleotide polymorphism) in the EOMES (Eomesodermin) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. Eomesodermin is a T-box transcription factor that drives cytotoxic CD8+ T cell differentiation, NK cell maturation, and memory T cell formation. It regulates perforin and granzyme expression in CTLs.
Biological role and pathway
This variant sits within the EOMES gene, which is involved in the T cell effector function pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs72935865 and Long COVID / ME-CFS research
Cytotoxic T cell exhaustion and NK cell dysfunction are documented in Long COVID. EOMES variants affecting CTL and NK cell function may impair viral clearance and immune surveillance, contributing to the persistent antigen exposure or viral reservoirs proposed in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: EOMES
rs72935865 is one of 2 known variants in the EOMES gene. To understand the full biological context of this variant, explore the parent gene page.
View EOMES gene page →Conditions studied in relation to rs72935865
Research into EOMES variants including rs72935865 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include EOMES and the rs72935865 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the EOMES gene
The following variants in EOMES are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs72935865 variant in the EOMES gene?
rs72935865 is a single nucleotide polymorphism (SNP) located in the EOMES (Eomesodermin) gene, which is involved in T cell effector function. Eomesodermin is a T-box transcription factor that drives cytotoxic CD8+ T cell differentiation, NK cell maturation, and memory T cell formation. It regulates perforin and granzyme expression in CTLs.
How may the rs72935865 variant relate to Long COVID or ME/CFS?
Cytotoxic T cell exhaustion and NK cell dysfunction are documented in Long COVID. EOMES variants affecting CTL and NK cell function may impair viral clearance and immune surveillance, contributing to the persistent antigen exposure or viral reservoirs proposed in Long COVID.
Can a consumer DNA test detect the rs72935865 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs72935865 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for EOMES and its variants. This is not an exhaustive literature review.
- [1]PMID: 27076434
- [2]Nature Immunology
- [3]Science