rs20551
Variant in the EP300 gene (E1A Binding Protein P300)
rs20551 is a single nucleotide polymorphism (SNP) in the EP300 gene, involved in histone acetyltransferase / transcriptional coactivator. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs20551 variant?
rs20551 is a SNP (single nucleotide polymorphism) in the EP300 (E1A Binding Protein P300) gene. It belongs to the Epigenetics category and is part of the Methylation & Neurotransmitters biological cluster. EP300 encodes p300, a histone acetyltransferase and transcriptional coactivator that activates gene expression by acetylating histones and transcription factors.
Biological role and pathway
This variant sits within the EP300 gene, which is involved in the histone acetyltransferase / transcriptional coactivator pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs20551 and Long COVID / ME-CFS research
p300-mediated histone acetylation is important for antiviral gene expression and NF-kB activation; variants may affect transcriptional responses to SARS-CoV-2 and inflammatory gene regulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: EP300
rs20551 is one of 1 known variant in the EP300 gene. To understand the full biological context of this variant, explore the parent gene page.
View EP300 gene page →Conditions studied in relation to rs20551
Research into EP300 variants including rs20551 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include EP300 and the rs20551 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs20551 variant in the EP300 gene?
rs20551 is a single nucleotide polymorphism (SNP) located in the EP300 (E1A Binding Protein P300) gene, which is involved in histone acetyltransferase / transcriptional coactivator. EP300 encodes p300, a histone acetyltransferase and transcriptional coactivator that activates gene expression by acetylating histones and transcription factors.
How may the rs20551 variant relate to Long COVID or ME/CFS?
p300-mediated histone acetylation is important for antiviral gene expression and NF-kB activation; variants may affect transcriptional responses to SARS-CoV-2 and inflammatory gene regulation in Long COVID.
Can a consumer DNA test detect the rs20551 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs20551 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for EP300 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Cell