rs2069952
Variant in the EPCR gene (Endothelial Protein C Receptor)
rs2069952 is a single nucleotide polymorphism (SNP) in the EPCR gene, involved in anticoagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2069952 variant?
rs2069952 is a SNP (single nucleotide polymorphism) in the EPCR (Endothelial Protein C Receptor) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. EPCR (PROCR) accelerates protein C activation by thrombin-thrombomodulin complexes and participates in cell signaling through PAR1. It maintains the anticoagulant and cytoprotective effects of activated protein C on endothelium.
Biological role and pathway
This variant sits within the EPCR gene, which is involved in the anticoagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2069952 and Long COVID / ME-CFS research
EPCR variants (particularly the H3 haplotype with rs867186) influence protein C anticoagulant pathway efficiency and venous thromboembolism risk. Impaired EPCR-mediated anticoagulation may exacerbate the COVID-19-associated coagulopathy extending into Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: EPCR
rs2069952 is one of 3 known variants in the EPCR gene. To understand the full biological context of this variant, explore the parent gene page.
View EPCR gene page →Conditions studied in relation to rs2069952
Research into EPCR variants including rs2069952 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include EPCR and the rs2069952 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the EPCR gene
The following variants in EPCR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2069952 variant in the EPCR gene?
rs2069952 is a single nucleotide polymorphism (SNP) located in the EPCR (Endothelial Protein C Receptor) gene, which is involved in anticoagulation. EPCR (PROCR) accelerates protein C activation by thrombin-thrombomodulin complexes and participates in cell signaling through PAR1. It maintains the anticoagulant and cytoprotective effects of activated protein C on endothelium.
How may the rs2069952 variant relate to Long COVID or ME/CFS?
EPCR variants (particularly the H3 haplotype with rs867186) influence protein C anticoagulant pathway efficiency and venous thromboembolism risk. Impaired EPCR-mediated anticoagulation may exacerbate the COVID-19-associated coagulopathy extending into Long COVID.
Can a consumer DNA test detect the rs2069952 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2069952 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for EPCR and its variants. This is not an exhaustive literature review.
- [1]PMID: 27987247
- [2]Blood
- [3]Journal of Thrombosis and Haemostasis