rs1136201
Variant in the ERBB2 gene (Erb-B2 Receptor Tyrosine Kinase 2 (HER2))
rs1136201 is a single nucleotide polymorphism (SNP) in the ERBB2 gene, involved in ErbB receptor signaling / tissue repair. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1136201 variant?
rs1136201 is a SNP (single nucleotide polymorphism) in the ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2 (HER2)) gene. It belongs to the Signaling category and is part of the Respiratory & Lung Function biological cluster. ERBB2 encodes HER2/ErbB2, which heterodimerizes with other ErbB receptors to amplify growth factor signaling in epithelial cells.
Biological role and pathway
This variant sits within the ERBB2 gene, which is involved in the ErbB receptor signaling / tissue repair pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1136201 and Long COVID / ME-CFS research
ERBB2 amplifies EGF family receptor signaling important for lung epithelial repair; variants may affect airway repair responses and susceptibility to fibrotic remodeling in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ERBB2
rs1136201 is one of 2 known variants in the ERBB2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ERBB2 gene page →Conditions studied in relation to rs1136201
Research into ERBB2 variants including rs1136201 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ERBB2 and the rs1136201 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ERBB2 gene
The following variants in ERBB2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1136201 variant in the ERBB2 gene?
rs1136201 is a single nucleotide polymorphism (SNP) located in the ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2 (HER2)) gene, which is involved in ErbB receptor signaling / tissue repair. ERBB2 encodes HER2/ErbB2, which heterodimerizes with other ErbB receptors to amplify growth factor signaling in epithelial cells.
How may the rs1136201 variant relate to Long COVID or ME/CFS?
ERBB2 amplifies EGF family receptor signaling important for lung epithelial repair; variants may affect airway repair responses and susceptibility to fibrotic remodeling in Long COVID.
Can a consumer DNA test detect the rs1136201 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1136201 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ERBB2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell