rs9340799
Variant in the ESR1 gene (Estrogen Receptor 1 (ERalpha))
rs9340799 is a single nucleotide polymorphism (SNP) in the ESR1 gene, involved in estrogen nuclear receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9340799 variant?
rs9340799 is a SNP (single nucleotide polymorphism) in the ESR1 (Estrogen Receptor 1 (ERalpha)) gene. It belongs to the Neuroendocrine category and is part of the Immune System & Inflammation biological cluster. ESR1 encodes estrogen receptor alpha (ERα), the major nuclear receptor mediating estrogen effects on gene expression, immune function, and cardiovascular biology.
Biological role and pathway
This variant sits within the ESR1 gene, which is involved in the estrogen nuclear receptor signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9340799 and Long COVID / ME-CFS research
Estrogen receptor signaling modulates immune responses and cardiovascular function; ESR1 variants may explain sex-based differences in Long COVID susceptibility and severity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ESR1
rs9340799 is one of 2 known variants in the ESR1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ESR1 gene page →Conditions studied in relation to rs9340799
Research into ESR1 variants including rs9340799 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ESR1 and the rs9340799 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ESR1 gene
The following variants in ESR1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9340799 variant in the ESR1 gene?
rs9340799 is a single nucleotide polymorphism (SNP) located in the ESR1 (Estrogen Receptor 1 (ERalpha)) gene, which is involved in estrogen nuclear receptor signaling. ESR1 encodes estrogen receptor alpha (ERα), the major nuclear receptor mediating estrogen effects on gene expression, immune function, and cardiovascular biology.
How may the rs9340799 variant relate to Long COVID or ME/CFS?
Estrogen receptor signaling modulates immune responses and cardiovascular function; ESR1 variants may explain sex-based differences in Long COVID susceptibility and severity.
Can a consumer DNA test detect the rs9340799 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9340799 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ESR1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Nature Medicine