rs3736228
Variant in the ESRRA gene (Estrogen Related Receptor Alpha)
rs3736228 is a single nucleotide polymorphism (SNP) in the ESRRA gene, involved in mitochondrial biogenesis / energy homeostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3736228 variant?
rs3736228 is a SNP (single nucleotide polymorphism) in the ESRRA (Estrogen Related Receptor Alpha) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. ESRRA encodes estrogen-related receptor alpha, a nuclear receptor that activates genes involved in mitochondrial biogenesis and oxidative phosphorylation.
Biological role and pathway
This variant sits within the ESRRA gene, which is involved in the mitochondrial biogenesis / energy homeostasis pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3736228 and Long COVID / ME-CFS research
ERR-alpha cooperates with PGC-1 coactivators to drive mitochondrial gene expression; variants may affect mitochondrial biogenesis capacity and contribute to energy deficits in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ESRRA
rs3736228 is one of 2 known variants in the ESRRA gene. To understand the full biological context of this variant, explore the parent gene page.
View ESRRA gene page →Conditions studied in relation to rs3736228
Research into ESRRA variants including rs3736228 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ESRRA and the rs3736228 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ESRRA gene
The following variants in ESRRA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3736228 variant in the ESRRA gene?
rs3736228 is a single nucleotide polymorphism (SNP) located in the ESRRA (Estrogen Related Receptor Alpha) gene, which is involved in mitochondrial biogenesis / energy homeostasis. ESRRA encodes estrogen-related receptor alpha, a nuclear receptor that activates genes involved in mitochondrial biogenesis and oxidative phosphorylation.
How may the rs3736228 variant relate to Long COVID or ME/CFS?
ERR-alpha cooperates with PGC-1 coactivators to drive mitochondrial gene expression; variants may affect mitochondrial biogenesis capacity and contribute to energy deficits in Long COVID.
Can a consumer DNA test detect the rs3736228 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3736228 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ESRRA and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Cell Metabolism
- [3]Nature Genetics