rs4241504
Variant in the F11 gene (Coagulation Factor XI)
rs4241504 is a single nucleotide polymorphism (SNP) in the F11 gene, involved in intrinsic coagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4241504 variant?
rs4241504 is a SNP (single nucleotide polymorphism) in the F11 (Coagulation Factor XI) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Factor XI (plasma thromboplastin antecedent) amplifies thrombin generation through the intrinsic pathway. Hemophilia C (FXI deficiency) causes mild bleeding; elevated FXI increases thrombotic risk.
Biological role and pathway
This variant sits within the F11 gene, which is involved in the intrinsic coagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4241504 and Long COVID / ME-CFS research
Elevated FXI levels are a risk factor for deep vein thrombosis and pulmonary embolism. F11 variants increasing FXI levels may compound COVID-19-associated coagulopathy and the persistent hypercoagulability observed in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: F11
rs4241504 is one of 3 known variants in the F11 gene. To understand the full biological context of this variant, explore the parent gene page.
View F11 gene page →Conditions studied in relation to rs4241504
Research into F11 variants including rs4241504 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include F11 and the rs4241504 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the F11 gene
The following variants in F11 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4241504 variant in the F11 gene?
rs4241504 is a single nucleotide polymorphism (SNP) located in the F11 (Coagulation Factor XI) gene, which is involved in intrinsic coagulation. Factor XI (plasma thromboplastin antecedent) amplifies thrombin generation through the intrinsic pathway. Hemophilia C (FXI deficiency) causes mild bleeding; elevated FXI increases thrombotic risk.
How may the rs4241504 variant relate to Long COVID or ME/CFS?
Elevated FXI levels are a risk factor for deep vein thrombosis and pulmonary embolism. F11 variants increasing FXI levels may compound COVID-19-associated coagulopathy and the persistent hypercoagulability observed in Long COVID.
Can a consumer DNA test detect the rs4241504 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4241504 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for F11 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29748392
- [2]Blood
- [3]New England Journal of Medicine