rs4524
Variant in the F13A1 gene (Coagulation Factor XIII A Chain)
rs4524 is a single nucleotide polymorphism (SNP) in the F13A1 gene, involved in fibrin crosslinking. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4524 variant?
rs4524 is a SNP (single nucleotide polymorphism) in the F13A1 (Coagulation Factor XIII A Chain) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Factor XIII (FXIII) crosslinks fibrin to form a stable clot and protects fibrin from fibrinolysis. The Val34Leu (rs5985) polymorphism affects FXIII activation rate by thrombin.
Biological role and pathway
This variant sits within the F13A1 gene, which is involved in the fibrin crosslinking pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4524 and Long COVID / ME-CFS research
FXIII-crosslinked fibrin is resistant to fibrinolysis. Variants affecting FXIII crosslinking efficiency may influence the density of microthrombi in Long COVID. The Val34Leu variant paradoxically reduces fibrin stability and may be protective against microthrombi in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: F13A1
rs4524 is one of 3 known variants in the F13A1 gene. To understand the full biological context of this variant, explore the parent gene page.
View F13A1 gene page →Conditions studied in relation to rs4524
Research into F13A1 variants including rs4524 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include F13A1 and the rs4524 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the F13A1 gene
The following variants in F13A1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4524 variant in the F13A1 gene?
rs4524 is a single nucleotide polymorphism (SNP) located in the F13A1 (Coagulation Factor XIII A Chain) gene, which is involved in fibrin crosslinking. Factor XIII (FXIII) crosslinks fibrin to form a stable clot and protects fibrin from fibrinolysis. The Val34Leu (rs5985) polymorphism affects FXIII activation rate by thrombin.
How may the rs4524 variant relate to Long COVID or ME/CFS?
FXIII-crosslinked fibrin is resistant to fibrinolysis. Variants affecting FXIII crosslinking efficiency may influence the density of microthrombi in Long COVID. The Val34Leu variant paradoxically reduces fibrin stability and may be protective against microthrombi in Long COVID.
Can a consumer DNA test detect the rs4524 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4524 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for F13A1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27162290
- [2]Blood
- [3]Thrombosis and Haemostasis