rs1799963

What is the rs1799963 variant?

rs1799963 is a SNP (single nucleotide polymorphism) in the F2 (Coagulation Factor II (Prothrombin)) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. F2 encodes prothrombin, which is cleaved to thrombin to drive fibrin clot formation; the G20210A variant increases prothrombin levels.

Biological role and pathway

This variant sits within the F2 gene, which is involved in the coagulation cascade pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: F2

rs1799963 is one of 1 known variant in the F2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1799963

Research into F2 variants including rs1799963 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include F2 and the rs1799963 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions