rs168753

What is the rs168753 variant?

rs168753 is a SNP (single nucleotide polymorphism) in the F2R (Coagulation Factor II Thrombin Receptor (PAR1)) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. F2R encodes PAR1 (protease-activated receptor 1), the main thrombin receptor on platelets and endothelial cells.

Biological role and pathway

This variant sits within the F2R gene, which is involved in the thrombin signaling / platelet activation / endothelial pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: F2R

rs168753 is one of 1 known variant in the F2R gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs168753

Research into F2R variants including rs168753 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include F2R and the rs168753 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions