rs6648
Variant in the F8 gene (Coagulation Factor VIII)
rs6648 is a single nucleotide polymorphism (SNP) in the F8 gene, involved in intrinsic coagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6648 variant?
rs6648 is a SNP (single nucleotide polymorphism) in the F8 (Coagulation Factor VIII) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Factor VIII (FVIII) is the cofactor for FIXa in the intrinsic tenase complex that activates FX. It circulates bound to von Willebrand factor. Deficiency causes Hemophilia A; elevated FVIII levels increase thrombotic risk.
Biological role and pathway
This variant sits within the F8 gene, which is involved in the intrinsic coagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6648 and Long COVID / ME-CFS research
Elevated FVIII levels are a major risk factor for venous thromboembolism and are elevated in COVID-19. VWF-bound FVIII is protected from degradation; the elevated VWF in COVID-19 endothelial activation may indirectly increase FVIII levels contributing to Long COVID hypercoagulability.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: F8
rs6648 is one of 3 known variants in the F8 gene. To understand the full biological context of this variant, explore the parent gene page.
View F8 gene page →Conditions studied in relation to rs6648
Research into F8 variants including rs6648 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include F8 and the rs6648 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the F8 gene
The following variants in F8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6648 variant in the F8 gene?
rs6648 is a single nucleotide polymorphism (SNP) located in the F8 (Coagulation Factor VIII) gene, which is involved in intrinsic coagulation. Factor VIII (FVIII) is the cofactor for FIXa in the intrinsic tenase complex that activates FX. It circulates bound to von Willebrand factor. Deficiency causes Hemophilia A; elevated FVIII levels increase thrombotic risk.
How may the rs6648 variant relate to Long COVID or ME/CFS?
Elevated FVIII levels are a major risk factor for venous thromboembolism and are elevated in COVID-19. VWF-bound FVIII is protected from degradation; the elevated VWF in COVID-19 endothelial activation may indirectly increase FVIII levels contributing to Long COVID hypercoagulability.
Can a consumer DNA test detect the rs6648 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6648 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for F8 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32678530
- [2]Blood
- [3]Nature Medicine