rs1800682

What is the rs1800682 variant?

rs1800682 is a SNP (single nucleotide polymorphism) in the FAS (Fas Cell Surface Death Receptor (CD95/APO-1)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. FAS encodes CD95/APO-1, a death receptor for Fas ligand that mediates apoptosis in lymphocytes and other cell types.

Biological role and pathway

This variant sits within the FAS gene, which is involved in the death receptor / apoptosis pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FAS

rs1800682 is one of 2 known variants in the FAS gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1800682

Research into FAS variants including rs1800682 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FAS and the rs1800682 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the FAS gene

The following variants in FAS are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions