rs2194462

What is the rs2194462 variant?

rs2194462 is a SNP (single nucleotide polymorphism) in the FASN (Fatty Acid Synthase) gene. It belongs to the Lipid Metabolism category and is part of the Lipid Metabolism biological cluster. FASN encodes fatty acid synthase, the multifunctional enzyme catalyzing de novo synthesis of palmitate from acetyl-CoA.

Biological role and pathway

This variant sits within the FASN gene, which is involved in the de novo fatty acid synthesis pathway. Genes within the Lipid Metabolism cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FASN

rs2194462 is one of 1 known variant in the FASN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2194462

Research into FASN variants including rs2194462 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FASN and the rs2194462 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions