rs1036477
Variant in the FBN1 gene (Fibrillin 1)
rs1036477 is a single nucleotide polymorphism (SNP) in the FBN1 gene, involved in elastic fiber formation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1036477 variant?
rs1036477 is a SNP (single nucleotide polymorphism) in the FBN1 (Fibrillin 1) gene. It belongs to the Connective Tissue category and is part of the Connective Tissue & EDS biological cluster. FBN1 encodes fibrillin-1, a glycoprotein that forms microfibrils in the extracellular matrix and sequesters TGF-beta.
Biological role and pathway
This variant sits within the FBN1 gene, which is involved in the elastic fiber formation pathway. Genes within the Connective Tissue & EDS cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1036477 and Long COVID / ME-CFS research
FBN1 mutations cause Marfan syndrome; common variants may influence connective tissue laxity and cardiovascular manifestations relevant to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FBN1
rs1036477 is one of 1 known variant in the FBN1 gene. To understand the full biological context of this variant, explore the parent gene page.
View FBN1 gene page →Conditions studied in relation to rs1036477
Research into FBN1 variants including rs1036477 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FBN1 and the rs1036477 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FBN1 gene
The following variants in FBN1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1036477 variant in the FBN1 gene?
rs1036477 is a single nucleotide polymorphism (SNP) located in the FBN1 (Fibrillin 1) gene, which is involved in elastic fiber formation. FBN1 encodes fibrillin-1, a glycoprotein that forms microfibrils in the extracellular matrix and sequesters TGF-beta.
How may the rs1036477 variant relate to Long COVID or ME/CFS?
FBN1 mutations cause Marfan syndrome; common variants may influence connective tissue laxity and cardiovascular manifestations relevant to Long COVID.
Can a consumer DNA test detect the rs1036477 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1036477 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FBN1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30962581
- [2]Nature Genetics
- [3]Journal of Clinical Investigation