rs1801274
Variant in the FCGR2A gene (Fc Gamma Receptor IIa (CD32a))
rs1801274 is a single nucleotide polymorphism (SNP) in the FCGR2A gene, involved in IgG antibody-mediated immune activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801274 variant?
rs1801274 is a SNP (single nucleotide polymorphism) in the FCGR2A (Fc Gamma Receptor IIa (CD32a)) gene. It belongs to the Immune Signaling category and is part of the Coagulation & Microcirculation biological cluster. FCGR2A encodes FcγRIIa, an activating IgG receptor on macrophages, monocytes, neutrophils, and platelets mediating immune complex-driven activation.
Biological role and pathway
This variant sits within the FCGR2A gene, which is involved in the IgG antibody-mediated immune activation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801274 and Long COVID / ME-CFS research
FCGR2A H131R variant affects IgG binding affinity; variants influence the efficiency of antibody-mediated viral clearance and the risk of immune complex-driven inflammation relevant to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FCGR2A
rs1801274 is one of 1 known variant in the FCGR2A gene. To understand the full biological context of this variant, explore the parent gene page.
View FCGR2A gene page →Conditions studied in relation to rs1801274
Research into FCGR2A variants including rs1801274 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FCGR2A and the rs1801274 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1801274 variant in the FCGR2A gene?
rs1801274 is a single nucleotide polymorphism (SNP) located in the FCGR2A (Fc Gamma Receptor IIa (CD32a)) gene, which is involved in IgG antibody-mediated immune activation. FCGR2A encodes FcγRIIa, an activating IgG receptor on macrophages, monocytes, neutrophils, and platelets mediating immune complex-driven activation.
How may the rs1801274 variant relate to Long COVID or ME/CFS?
FCGR2A H131R variant affects IgG binding affinity; variants influence the efficiency of antibody-mediated viral clearance and the risk of immune complex-driven inflammation relevant to Long COVID.
Can a consumer DNA test detect the rs1801274 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801274 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FCGR2A and its variants. This is not an exhaustive literature review.
- [1]PMID: 32558485
- [2]Nature Genetics
- [3]Journal of Infectious Diseases