rs3219018
Variant in the FCGR2B gene (Fc Gamma Receptor IIb (CD32b))
rs3219018 is a single nucleotide polymorphism (SNP) in the FCGR2B gene, involved in IgG inhibitory signaling / B cell regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3219018 variant?
rs3219018 is a SNP (single nucleotide polymorphism) in the FCGR2B (Fc Gamma Receptor IIb (CD32b)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. FCGR2B encodes FcγRIIb, the only inhibitory Fc receptor that dampens B cell and macrophage activation.
Biological role and pathway
This variant sits within the FCGR2B gene, which is involved in the IgG inhibitory signaling / B cell regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3219018 and Long COVID / ME-CFS research
FCGR2B regulates B cell activation and antibody production; variants may affect autoantibody formation and the risk of immune complex disease in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FCGR2B
rs3219018 is one of 2 known variants in the FCGR2B gene. To understand the full biological context of this variant, explore the parent gene page.
View FCGR2B gene page →Conditions studied in relation to rs3219018
Research into FCGR2B variants including rs3219018 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FCGR2B and the rs3219018 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FCGR2B gene
The following variants in FCGR2B are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3219018 variant in the FCGR2B gene?
rs3219018 is a single nucleotide polymorphism (SNP) located in the FCGR2B (Fc Gamma Receptor IIb (CD32b)) gene, which is involved in IgG inhibitory signaling / B cell regulation. FCGR2B encodes FcγRIIb, the only inhibitory Fc receptor that dampens B cell and macrophage activation.
How may the rs3219018 variant relate to Long COVID or ME/CFS?
FCGR2B regulates B cell activation and antibody production; variants may affect autoantibody formation and the risk of immune complex disease in Long COVID.
Can a consumer DNA test detect the rs3219018 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3219018 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FCGR2B and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]NEJM