rs2074056
Variant in the FFAR2 gene (Free Fatty Acid Receptor 2)
rs2074056 is a single nucleotide polymorphism (SNP) in the FFAR2 gene, involved in SCFA signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2074056 variant?
rs2074056 is a SNP (single nucleotide polymorphism) in the FFAR2 (Free Fatty Acid Receptor 2) gene. It belongs to the Gut Microbiome category and is part of the Gut-Brain Axis biological cluster. FFAR2 (GPR43) is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) produced by gut microbiota fermentation, particularly acetate and propionate. It mediates gut-immune crosstalk and regulates inflammatory tone.
Biological role and pathway
This variant sits within the FFAR2 gene, which is involved in the SCFA signaling pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2074056 and Long COVID / ME-CFS research
Gut dysbiosis with reduced SCFA-producing bacteria is documented in COVID-19 and Long COVID. FFAR2 variants affecting SCFA sensing may impair the gut-immune regulatory axis, contributing to the systemic inflammation and gut symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FFAR2
rs2074056 is one of 3 known variants in the FFAR2 gene. To understand the full biological context of this variant, explore the parent gene page.
View FFAR2 gene page →Conditions studied in relation to rs2074056
Research into FFAR2 variants including rs2074056 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FFAR2 and the rs2074056 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FFAR2 gene
The following variants in FFAR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2074056 variant in the FFAR2 gene?
rs2074056 is a single nucleotide polymorphism (SNP) located in the FFAR2 (Free Fatty Acid Receptor 2) gene, which is involved in SCFA signaling. FFAR2 (GPR43) is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) produced by gut microbiota fermentation, particularly acetate and propionate. It mediates gut-immune crosstalk and regulates inflammatory tone.
How may the rs2074056 variant relate to Long COVID or ME/CFS?
Gut dysbiosis with reduced SCFA-producing bacteria is documented in COVID-19 and Long COVID. FFAR2 variants affecting SCFA sensing may impair the gut-immune regulatory axis, contributing to the systemic inflammation and gut symptoms in Long COVID.
Can a consumer DNA test detect the rs2074056 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2074056 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FFAR2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30837344
- [2]Nature Reviews Gastroenterology
- [3]Cell Host & Microbe