rs2074058

What is the rs2074058 variant?

rs2074058 is a SNP (single nucleotide polymorphism) in the FFAR3 (Free Fatty Acid Receptor 3) gene. It belongs to the Gut Microbiome category and is part of the Gut-Brain Axis biological cluster. FFAR3 (GPR41) responds primarily to propionate and butyrate and is expressed in enteroendocrine cells and the sympathetic nervous system, connecting gut microbial metabolism to autonomic regulation.

Biological role and pathway

This variant sits within the FFAR3 gene, which is involved in the SCFA signaling pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FFAR3

rs2074058 is one of 2 known variants in the FFAR3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2074058

Research into FFAR3 variants including rs2074058 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FFAR3 and the rs2074058 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the FFAR3 gene

The following variants in FFAR3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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