rs1800790
Variant in the FGA gene (Fibrinogen Alpha Chain)
rs1800790 is a single nucleotide polymorphism (SNP) in the FGA gene, involved in fibrin formation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800790 variant?
rs1800790 is a SNP (single nucleotide polymorphism) in the FGA (Fibrinogen Alpha Chain) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. FGA encodes the alpha chain of fibrinogen, the precursor of fibrin. The FGA Thr312Ala variant affects fibrin clot structure and stability, influencing thrombotic risk. Fibrinogen is also an acute phase reactant.
Biological role and pathway
This variant sits within the FGA gene, which is involved in the fibrin formation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800790 and Long COVID / ME-CFS research
Elevated fibrinogen is a biomarker of COVID-19 severity and persists in Long COVID. Amyloid fibrin microclots resistant to fibrinolysis have been found in Long COVID blood. FGA variants affecting fibrin polymerization may influence microclot formation propensity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FGA
rs1800790 is one of 3 known variants in the FGA gene. To understand the full biological context of this variant, explore the parent gene page.
View FGA gene page →Conditions studied in relation to rs1800790
Research into FGA variants including rs1800790 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FGA and the rs1800790 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FGA gene
The following variants in FGA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800790 variant in the FGA gene?
rs1800790 is a single nucleotide polymorphism (SNP) located in the FGA (Fibrinogen Alpha Chain) gene, which is involved in fibrin formation. FGA encodes the alpha chain of fibrinogen, the precursor of fibrin. The FGA Thr312Ala variant affects fibrin clot structure and stability, influencing thrombotic risk. Fibrinogen is also an acute phase reactant.
How may the rs1800790 variant relate to Long COVID or ME/CFS?
Elevated fibrinogen is a biomarker of COVID-19 severity and persists in Long COVID. Amyloid fibrin microclots resistant to fibrinolysis have been found in Long COVID blood. FGA variants affecting fibrin polymerization may influence microclot formation propensity.
Can a consumer DNA test detect the rs1800790 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800790 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FGA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32926228
- [2]Nature Medicine
- [3]Blood