rs2071385
Variant in the FGF23 gene (Fibroblast Growth Factor 23)
rs2071385 is a single nucleotide polymorphism (SNP) in the FGF23 gene, involved in phosphate homeostasis / vitamin D regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2071385 variant?
rs2071385 is a SNP (single nucleotide polymorphism) in the FGF23 (Fibroblast Growth Factor 23) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. FGF23 encodes FGF-23, a bone-derived hormone that regulates phosphate reabsorption and vitamin D metabolism in the kidney.
Biological role and pathway
This variant sits within the FGF23 gene, which is involved in the phosphate homeostasis / vitamin D regulation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2071385 and Long COVID / ME-CFS research
FGF23 is elevated during inflammation and infection; elevated FGF23 in COVID-19 and Long COVID may impair vitamin D activation and renal phosphate handling, affecting energy metabolism.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FGF23
rs2071385 is one of 2 known variants in the FGF23 gene. To understand the full biological context of this variant, explore the parent gene page.
View FGF23 gene page →Conditions studied in relation to rs2071385
Research into FGF23 variants including rs2071385 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FGF23 and the rs2071385 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FGF23 gene
The following variants in FGF23 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2071385 variant in the FGF23 gene?
rs2071385 is a single nucleotide polymorphism (SNP) located in the FGF23 (Fibroblast Growth Factor 23) gene, which is involved in phosphate homeostasis / vitamin D regulation. FGF23 encodes FGF-23, a bone-derived hormone that regulates phosphate reabsorption and vitamin D metabolism in the kidney.
How may the rs2071385 variant relate to Long COVID or ME/CFS?
FGF23 is elevated during inflammation and infection; elevated FGF23 in COVID-19 and Long COVID may impair vitamin D activation and renal phosphate handling, affecting energy metabolism.
Can a consumer DNA test detect the rs2071385 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2071385 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FGF23 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]JCEM