rs1049636
Variant in the FGG gene (Fibrinogen Gamma Chain)
rs1049636 is a single nucleotide polymorphism (SNP) in the FGG gene, involved in fibrin formation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1049636 variant?
rs1049636 is a SNP (single nucleotide polymorphism) in the FGG (Fibrinogen Gamma Chain) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. FGG encodes the gamma chain of fibrinogen. The gamma' splice variant influences fibrin clot structure and platelet binding. FGG variants affect thrombotic risk and plasma fibrinogen gamma' levels.
Biological role and pathway
This variant sits within the FGG gene, which is involved in the fibrin formation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1049636 and Long COVID / ME-CFS research
Fibrinogen gamma variants modulate clot structure, fibrinolysis resistance, and platelet interactions. In Long COVID, altered fibrin clot architecture may contribute to hypofibrinolysis and microthrombi persistence, with FGG variants potentially influencing this phenotype.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FGG
rs1049636 is one of 3 known variants in the FGG gene. To understand the full biological context of this variant, explore the parent gene page.
View FGG gene page →Conditions studied in relation to rs1049636
Research into FGG variants including rs1049636 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FGG and the rs1049636 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FGG gene
The following variants in FGG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1049636 variant in the FGG gene?
rs1049636 is a single nucleotide polymorphism (SNP) located in the FGG (Fibrinogen Gamma Chain) gene, which is involved in fibrin formation. FGG encodes the gamma chain of fibrinogen. The gamma' splice variant influences fibrin clot structure and platelet binding. FGG variants affect thrombotic risk and plasma fibrinogen gamma' levels.
How may the rs1049636 variant relate to Long COVID or ME/CFS?
Fibrinogen gamma variants modulate clot structure, fibrinolysis resistance, and platelet interactions. In Long COVID, altered fibrin clot architecture may contribute to hypofibrinolysis and microthrombi persistence, with FGG variants potentially influencing this phenotype.
Can a consumer DNA test detect the rs1049636 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1049636 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FGG and its variants. This is not an exhaustive literature review.
- [1]PMID: 25904512
- [2]Blood
- [3]Thrombosis and Haemostasis