rs9470080
Variant in the FKBP5 gene (FKBP Prolyl Isomerase 5)
rs9470080 is a single nucleotide polymorphism (SNP) in the FKBP5 gene, involved in glucocorticoid receptor regulation / stress response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9470080 variant?
rs9470080 is a SNP (single nucleotide polymorphism) in the FKBP5 (FKBP Prolyl Isomerase 5) gene. It belongs to the Immune Signaling category and is part of the Autonomic Nervous System biological cluster. FKBP5 encodes FK506-binding protein 51, a co-chaperone that regulates glucocorticoid receptor sensitivity and HPA axis reactivity.
Biological role and pathway
This variant sits within the FKBP5 gene, which is involved in the glucocorticoid receptor regulation / stress response pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9470080 and Long COVID / ME-CFS research
FKBP5 variants affect cortisol sensitivity and HPA axis function; they are strongly associated with stress-related conditions and may contribute to dysregulated stress responses and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FKBP5
rs9470080 is one of 3 known variants in the FKBP5 gene. To understand the full biological context of this variant, explore the parent gene page.
View FKBP5 gene page →Conditions studied in relation to rs9470080
Research into FKBP5 variants including rs9470080 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FKBP5 and the rs9470080 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FKBP5 gene
The following variants in FKBP5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9470080 variant in the FKBP5 gene?
rs9470080 is a single nucleotide polymorphism (SNP) located in the FKBP5 (FKBP Prolyl Isomerase 5) gene, which is involved in glucocorticoid receptor regulation / stress response. FKBP5 encodes FK506-binding protein 51, a co-chaperone that regulates glucocorticoid receptor sensitivity and HPA axis reactivity.
How may the rs9470080 variant relate to Long COVID or ME/CFS?
FKBP5 variants affect cortisol sensitivity and HPA axis function; they are strongly associated with stress-related conditions and may contribute to dysregulated stress responses and fatigue in Long COVID.
Can a consumer DNA test detect the rs9470080 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9470080 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FKBP5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Molecular Psychiatry