rs1250258
Variant in the FN1 gene (Fibronectin 1)
rs1250258 is a single nucleotide polymorphism (SNP) in the FN1 gene, involved in extracellular matrix / cell adhesion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1250258 variant?
rs1250258 is a SNP (single nucleotide polymorphism) in the FN1 (Fibronectin 1) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. FN1 encodes fibronectin, an extracellular matrix glycoprotein critical for cell adhesion, migration, wound healing, and tissue repair.
Biological role and pathway
This variant sits within the FN1 gene, which is involved in the extracellular matrix / cell adhesion pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1250258 and Long COVID / ME-CFS research
Fibronectin is involved in tissue repair and inflammation; elevated fibronectin in COVID-19 and post-COVID fibrotic changes may be influenced by FN1 variants.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FN1
rs1250258 is one of 2 known variants in the FN1 gene. To understand the full biological context of this variant, explore the parent gene page.
View FN1 gene page →Conditions studied in relation to rs1250258
Research into FN1 variants including rs1250258 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FN1 and the rs1250258 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FN1 gene
The following variants in FN1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1250258 variant in the FN1 gene?
rs1250258 is a single nucleotide polymorphism (SNP) located in the FN1 (Fibronectin 1) gene, which is involved in extracellular matrix / cell adhesion. FN1 encodes fibronectin, an extracellular matrix glycoprotein critical for cell adhesion, migration, wound healing, and tissue repair.
How may the rs1250258 variant relate to Long COVID or ME/CFS?
Fibronectin is involved in tissue repair and inflammation; elevated fibronectin in COVID-19 and post-COVID fibrotic changes may be influenced by FN1 variants.
Can a consumer DNA test detect the rs1250258 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1250258 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for FN1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Matrix Biology