rs1573621

What is the rs1573621 variant?

rs1573621 is a SNP (single nucleotide polymorphism) in the FOXA2 (Forkhead Box A2) gene. It belongs to the Respiratory category and is part of the Respiratory & Lung Function biological cluster. FOXA2 encodes a pioneer transcription factor critical for lung, liver, and pancreatic gene regulation.

Biological role and pathway

This variant sits within the FOXA2 gene, which is involved in the lung development / hepatic gene regulation pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FOXA2

rs1573621 is one of 1 known variant in the FOXA2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1573621

Research into FOXA2 variants including rs1573621 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FOXA2 and the rs1573621 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions