rs1049331

What is the rs1049331 variant?

rs1049331 is a SNP (single nucleotide polymorphism) in the FTH1 (Ferritin Heavy Chain 1) gene. It belongs to the Metabolic category and is part of the Oxidative Stress biological cluster. FTH1 encodes ferritin heavy chain, which stores iron safely in ferritin and provides protection against iron-mediated oxidative damage.

Biological role and pathway

This variant sits within the FTH1 gene, which is involved in the iron storage / ferroptosis protection pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FTH1

rs1049331 is one of 1 known variant in the FTH1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1049331

Research into FTH1 variants including rs1049331 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FTH1 and the rs1049331 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions