rs2521501

What is the rs2521501 variant?

rs2521501 is a SNP (single nucleotide polymorphism) in the FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. FURIN encodes a proprotein convertase that cleaves at RXKR motifs; it activates SARS-CoV-2 spike at the S1/S2 furin cleavage site, a feature unique to SARS-CoV-2.

Biological role and pathway

This variant sits within the FURIN gene, which is involved in the proprotein convertase / viral protein activation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: FURIN

rs2521501 is one of 2 known variants in the FURIN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2521501

Research into FURIN variants including rs2521501 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FURIN and the rs2521501 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the FURIN gene

The following variants in FURIN are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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