rs769395

What is the rs769395 variant?

rs769395 is a SNP (single nucleotide polymorphism) in the GAD1 (Glutamate Decarboxylase 1) gene. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. GAD1 encodes glutamic acid decarboxylase 1 (GAD67), which converts glutamate to GABA, the primary inhibitory neurotransmitter.

Biological role and pathway

This variant sits within the GAD1 gene, which is involved in the GABA biosynthesis pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: GAD1

rs769395 is one of 1 known variant in the GAD1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs769395

Research into GAD1 variants including rs769395 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GAD1 and the rs769395 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions