rs2070935
Variant in the GFAP gene (Glial Fibrillary Acidic Protein)
rs2070935 is a single nucleotide polymorphism (SNP) in the GFAP gene, involved in astrocyte structural protein / neuroinflammation biomarker. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2070935 variant?
rs2070935 is a SNP (single nucleotide polymorphism) in the GFAP (Glial Fibrillary Acidic Protein) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. GFAP encodes the main intermediate filament protein of astrocytes; serum GFAP is a biomarker of astrocyte activation and brain injury.
Biological role and pathway
This variant sits within the GFAP gene, which is involved in the astrocyte structural protein / neuroinflammation biomarker pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2070935 and Long COVID / ME-CFS research
Serum GFAP is elevated in COVID-19 and Long COVID, reflecting astrocyte activation and brain damage; GFAP variants may influence astrocyte reactivity and the neuroinflammatory response in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GFAP
rs2070935 is one of 2 known variants in the GFAP gene. To understand the full biological context of this variant, explore the parent gene page.
View GFAP gene page →Conditions studied in relation to rs2070935
Research into GFAP variants including rs2070935 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GFAP and the rs2070935 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GFAP gene
The following variants in GFAP are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2070935 variant in the GFAP gene?
rs2070935 is a single nucleotide polymorphism (SNP) located in the GFAP (Glial Fibrillary Acidic Protein) gene, which is involved in astrocyte structural protein / neuroinflammation biomarker. GFAP encodes the main intermediate filament protein of astrocytes; serum GFAP is a biomarker of astrocyte activation and brain injury.
How may the rs2070935 variant relate to Long COVID or ME/CFS?
Serum GFAP is elevated in COVID-19 and Long COVID, reflecting astrocyte activation and brain damage; GFAP variants may influence astrocyte reactivity and the neuroinflammatory response in Long COVID.
Can a consumer DNA test detect the rs2070935 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2070935 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GFAP and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Medicine
- [3]Cell