rs699664
Variant in the GGCX gene (Gamma-Glutamyl Carboxylase)
rs699664 is a single nucleotide polymorphism (SNP) in the GGCX gene, involved in vitamin K cycle. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs699664 variant?
rs699664 is a SNP (single nucleotide polymorphism) in the GGCX (Gamma-Glutamyl Carboxylase) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. GGCX carboxylates glutamic acid residues on vitamin K-dependent proteins including coagulation factors, osteocalcin, and matrix Gla protein (MGP). This modification is essential for calcium binding and proper protein function.
Biological role and pathway
This variant sits within the GGCX gene, which is involved in the vitamin K cycle pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs699664 and Long COVID / ME-CFS research
Matrix Gla protein (MGP) requires GGCX-mediated carboxylation to inhibit vascular calcification. Low vitamin K2 with impaired GGCX activity may increase vascular calcification risk — relevant to the cardiovascular complications observed in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GGCX
rs699664 is one of 3 known variants in the GGCX gene. To understand the full biological context of this variant, explore the parent gene page.
View GGCX gene page →Conditions studied in relation to rs699664
Research into GGCX variants including rs699664 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GGCX and the rs699664 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GGCX gene
The following variants in GGCX are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs699664 variant in the GGCX gene?
rs699664 is a single nucleotide polymorphism (SNP) located in the GGCX (Gamma-Glutamyl Carboxylase) gene, which is involved in vitamin K cycle. GGCX carboxylates glutamic acid residues on vitamin K-dependent proteins including coagulation factors, osteocalcin, and matrix Gla protein (MGP). This modification is essential for calcium binding and proper protein function.
How may the rs699664 variant relate to Long COVID or ME/CFS?
Matrix Gla protein (MGP) requires GGCX-mediated carboxylation to inhibit vascular calcification. Low vitamin K2 with impaired GGCX activity may increase vascular calcification risk — relevant to the cardiovascular complications observed in Long COVID.
Can a consumer DNA test detect the rs699664 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs699664 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GGCX and its variants. This is not an exhaustive literature review.
- [1]PMID: 25948572
- [2]Blood
- [3]Arteriosclerosis Thrombosis and Vascular Biology