rs2665802

Variant in the GH1 gene (Growth Hormone 1)

rs2665802 is a single nucleotide polymorphism (SNP) in the GH1 gene, involved in somatotropic axis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.

This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.

What is the rs2665802 variant?

rs2665802 is a SNP (single nucleotide polymorphism) in the GH1 (Growth Hormone 1) gene. It belongs to the Hormonal category and is part of the Hormonal Regulation biological cluster. GH1 encodes growth hormone, a pituitary hormone regulating growth, metabolism, immune function, and tissue repair.

Biological role and pathway

This variant sits within the GH1 gene, which is involved in the somatotropic axis pathway. Genes within the Hormonal Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

rs2665802 and Long COVID / ME-CFS research

Growth hormone axis dysfunction has been proposed as a contributor to fatigue and muscle weakness in Long COVID.

This information is based on published research and does not constitute medical advice. See references below.

Parent gene: GH1

rs2665802 is one of 1 known variant in the GH1 gene. To understand the full biological context of this variant, explore the parent gene page.

View GH1 gene page →

Conditions studied in relation to rs2665802

Research into GH1 variants including rs2665802 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GH1 and the rs2665802 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions

What is the rs2665802 variant in the GH1 gene?

rs2665802 is a single nucleotide polymorphism (SNP) located in the GH1 (Growth Hormone 1) gene, which is involved in somatotropic axis. GH1 encodes growth hormone, a pituitary hormone regulating growth, metabolism, immune function, and tissue repair.

How may the rs2665802 variant relate to Long COVID or ME/CFS?

Growth hormone axis dysfunction has been proposed as a contributor to fatigue and muscle weakness in Long COVID.

Can a consumer DNA test detect the rs2665802 variant?

Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.

Find out if you carry the rs2665802 variant

Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.

Get Your Personalised DNA Report

Informational and educational only · Not a diagnostic tool · GDPR compliant

References

The following publications were used in compiling the research context for GH1 and its variants. This is not an exhaustive literature review.

  • [1]PMID: 32972995
  • [2]Nature Genetics
  • [3]Journal of Clinical Investigation