rs6873545
Variant in the GHR gene (Growth Hormone Receptor)
rs6873545 is a single nucleotide polymorphism (SNP) in the GHR gene, involved in growth hormone / JAK2-STAT5 signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6873545 variant?
rs6873545 is a SNP (single nucleotide polymorphism) in the GHR (Growth Hormone Receptor) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. GHR encodes the growth hormone receptor, which activates JAK2 and STAT5 to mediate GH effects on growth and metabolism.
Biological role and pathway
This variant sits within the GHR gene, which is involved in the growth hormone / JAK2-STAT5 signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6873545 and Long COVID / ME-CFS research
GH receptor signaling regulates IGF-1 production and metabolic functions; GHR variants (especially Exon 3 deletion) may affect IGF-1 levels and anabolic tissue maintenance in Long COVID recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GHR
rs6873545 is one of 2 known variants in the GHR gene. To understand the full biological context of this variant, explore the parent gene page.
View GHR gene page →Conditions studied in relation to rs6873545
Research into GHR variants including rs6873545 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GHR and the rs6873545 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GHR gene
The following variants in GHR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6873545 variant in the GHR gene?
rs6873545 is a single nucleotide polymorphism (SNP) located in the GHR (Growth Hormone Receptor) gene, which is involved in growth hormone / JAK2-STAT5 signaling. GHR encodes the growth hormone receptor, which activates JAK2 and STAT5 to mediate GH effects on growth and metabolism.
How may the rs6873545 variant relate to Long COVID or ME/CFS?
GH receptor signaling regulates IGF-1 production and metabolic functions; GHR variants (especially Exon 3 deletion) may affect IGF-1 levels and anabolic tissue maintenance in Long COVID recovery.
Can a consumer DNA test detect the rs6873545 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6873545 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GHR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]JCEM