rs2268574
Variant in the GLP1R gene (Glucagon Like Peptide 1 Receptor)
rs2268574 is a single nucleotide polymorphism (SNP) in the GLP1R gene, involved in incretin signaling / insulin secretion / inflammation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2268574 variant?
rs2268574 is a SNP (single nucleotide polymorphism) in the GLP1R (Glucagon Like Peptide 1 Receptor) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. GLP1R encodes the GLP-1 receptor, the target of semaglutide and other GLP-1 agonist drugs, mediating incretin effects on beta cells and the brain.
Biological role and pathway
This variant sits within the GLP1R gene, which is involved in the incretin signaling / insulin secretion / inflammation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2268574 and Long COVID / ME-CFS research
GLP-1R agonists have anti-inflammatory effects and improve metabolic dysfunction; GLP1R variants may affect GLP-1 responsiveness and the potential benefit of GLP-1 agonists in Long COVID metabolic complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GLP1R
rs2268574 is one of 2 known variants in the GLP1R gene. To understand the full biological context of this variant, explore the parent gene page.
View GLP1R gene page →Conditions studied in relation to rs2268574
Research into GLP1R variants including rs2268574 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GLP1R and the rs2268574 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GLP1R gene
The following variants in GLP1R are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2268574 variant in the GLP1R gene?
rs2268574 is a single nucleotide polymorphism (SNP) located in the GLP1R (Glucagon Like Peptide 1 Receptor) gene, which is involved in incretin signaling / insulin secretion / inflammation. GLP1R encodes the GLP-1 receptor, the target of semaglutide and other GLP-1 agonist drugs, mediating incretin effects on beta cells and the brain.
How may the rs2268574 variant relate to Long COVID or ME/CFS?
GLP-1R agonists have anti-inflammatory effects and improve metabolic dysfunction; GLP1R variants may affect GLP-1 responsiveness and the potential benefit of GLP-1 agonists in Long COVID metabolic complications.
Can a consumer DNA test detect the rs2268574 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2268574 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GLP1R and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM