rs2188723
Variant in the GOT1 gene (Glutamic-Oxaloacetic Transaminase 1)
rs2188723 is a single nucleotide polymorphism (SNP) in the GOT1 gene, involved in aspartate aminotransferase / TCA cycle. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2188723 variant?
rs2188723 is a SNP (single nucleotide polymorphism) in the GOT1 (Glutamic-Oxaloacetic Transaminase 1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. GOT1 encodes cytosolic aspartate aminotransferase (AST), which interconverts oxaloacetate and aspartate, linking TCA cycle to amino acid metabolism.
Biological role and pathway
This variant sits within the GOT1 gene, which is involved in the aspartate aminotransferase / TCA cycle pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2188723 and Long COVID / ME-CFS research
Elevated GOT1/AST is a marker of liver and muscle damage in COVID-19; variants may affect AST levels and metabolic flux through the TCA cycle in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GOT1
rs2188723 is one of 1 known variant in the GOT1 gene. To understand the full biological context of this variant, explore the parent gene page.
View GOT1 gene page →Conditions studied in relation to rs2188723
Research into GOT1 variants including rs2188723 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GOT1 and the rs2188723 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs2188723 variant in the GOT1 gene?
rs2188723 is a single nucleotide polymorphism (SNP) located in the GOT1 (Glutamic-Oxaloacetic Transaminase 1) gene, which is involved in aspartate aminotransferase / TCA cycle. GOT1 encodes cytosolic aspartate aminotransferase (AST), which interconverts oxaloacetate and aspartate, linking TCA cycle to amino acid metabolism.
How may the rs2188723 variant relate to Long COVID or ME/CFS?
Elevated GOT1/AST is a marker of liver and muscle damage in COVID-19; variants may affect AST levels and metabolic flux through the TCA cycle in Long COVID.
Can a consumer DNA test detect the rs2188723 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2188723 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GOT1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Hepatology