rs7298043
Variant in the GRIN2B gene (Glutamate Ionotropic Receptor NMDA Type Subunit 2B)
rs7298043 is a single nucleotide polymorphism (SNP) in the GRIN2B gene, involved in NMDA receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7298043 variant?
rs7298043 is a SNP (single nucleotide polymorphism) in the GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B) gene. It belongs to the Neuroplasticity category and is part of the Neurological & Cognitive Function biological cluster. GRIN2B encodes the GluN2B NMDA receptor subunit, which has key roles in synaptic plasticity, learning, and memory.
Biological role and pathway
This variant sits within the GRIN2B gene, which is involved in the NMDA receptor signaling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7298043 and Long COVID / ME-CFS research
GRIN2B-dependent NMDA receptor function underpins memory encoding; variants may contribute to cognitive deficits in Long COVID brain fog.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GRIN2B
rs7298043 is one of 2 known variants in the GRIN2B gene. To understand the full biological context of this variant, explore the parent gene page.
View GRIN2B gene page →Conditions studied in relation to rs7298043
Research into GRIN2B variants including rs7298043 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GRIN2B and the rs7298043 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GRIN2B gene
The following variants in GRIN2B are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7298043 variant in the GRIN2B gene?
rs7298043 is a single nucleotide polymorphism (SNP) located in the GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B) gene, which is involved in NMDA receptor signaling. GRIN2B encodes the GluN2B NMDA receptor subunit, which has key roles in synaptic plasticity, learning, and memory.
How may the rs7298043 variant relate to Long COVID or ME/CFS?
GRIN2B-dependent NMDA receptor function underpins memory encoding; variants may contribute to cognitive deficits in Long COVID brain fog.
Can a consumer DNA test detect the rs7298043 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7298043 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GRIN2B and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Clinical Investigation