rs3761554
Variant in the GRM5 gene (Glutamate Metabotropic Receptor 5 (mGluR5))
rs3761554 is a single nucleotide polymorphism (SNP) in the GRM5 gene, involved in metabotropic glutamate / synaptic modulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3761554 variant?
rs3761554 is a SNP (single nucleotide polymorphism) in the GRM5 (Glutamate Metabotropic Receptor 5 (mGluR5)) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. GRM5 encodes mGluR5, a metabotropic glutamate receptor that modulates synaptic transmission and is involved in anxiety, pain, and cognition.
Biological role and pathway
This variant sits within the GRM5 gene, which is involved in the metabotropic glutamate / synaptic modulation pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3761554 and Long COVID / ME-CFS research
GRM5 modulates glutamatergic neurotransmission; variants may affect pain sensitization and cognitive function in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GRM5
rs3761554 is one of 1 known variant in the GRM5 gene. To understand the full biological context of this variant, explore the parent gene page.
View GRM5 gene page →Conditions studied in relation to rs3761554
Research into GRM5 variants including rs3761554 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GRM5 and the rs3761554 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs3761554 variant in the GRM5 gene?
rs3761554 is a single nucleotide polymorphism (SNP) located in the GRM5 (Glutamate Metabotropic Receptor 5 (mGluR5)) gene, which is involved in metabotropic glutamate / synaptic modulation. GRM5 encodes mGluR5, a metabotropic glutamate receptor that modulates synaptic transmission and is involved in anxiety, pain, and cognition.
How may the rs3761554 variant relate to Long COVID or ME/CFS?
GRM5 modulates glutamatergic neurotransmission; variants may affect pain sensitization and cognitive function in Long COVID.
Can a consumer DNA test detect the rs3761554 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3761554 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GRM5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Neuroscience