rs6438552
Variant in the GSK3B gene (Glycogen Synthase Kinase 3 Beta)
rs6438552 is a single nucleotide polymorphism (SNP) in the GSK3B gene, involved in Wnt/AMPK/glycogen metabolism signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6438552 variant?
rs6438552 is a SNP (single nucleotide polymorphism) in the GSK3B (Glycogen Synthase Kinase 3 Beta) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. GSK3B encodes a serine/threonine kinase involved in glycogen metabolism, circadian rhythm, Wnt signaling, and inflammatory gene regulation.
Biological role and pathway
This variant sits within the GSK3B gene, which is involved in the Wnt/AMPK/glycogen metabolism signaling pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6438552 and Long COVID / ME-CFS research
GSK3B is a convergence point for multiple Long COVID-relevant pathways including circadian disruption, metabolic dysfunction, and neuroinflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GSK3B
rs6438552 is one of 2 known variants in the GSK3B gene. To understand the full biological context of this variant, explore the parent gene page.
View GSK3B gene page →Conditions studied in relation to rs6438552
Research into GSK3B variants including rs6438552 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GSK3B and the rs6438552 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GSK3B gene
The following variants in GSK3B are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6438552 variant in the GSK3B gene?
rs6438552 is a single nucleotide polymorphism (SNP) located in the GSK3B (Glycogen Synthase Kinase 3 Beta) gene, which is involved in Wnt/AMPK/glycogen metabolism signaling. GSK3B encodes a serine/threonine kinase involved in glycogen metabolism, circadian rhythm, Wnt signaling, and inflammatory gene regulation.
How may the rs6438552 variant relate to Long COVID or ME/CFS?
GSK3B is a convergence point for multiple Long COVID-relevant pathways including circadian disruption, metabolic dysfunction, and neuroinflammation.
Can a consumer DNA test detect the rs6438552 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6438552 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for GSK3B and its variants. This is not an exhaustive literature review.
- [1]PMID: 32127339
- [2]Nature Genetics
- [3]Journal of Clinical Investigation